Rotaviral Enterotoxin Nonstructural Protein 4 Targets Mitochondria for Activation of Apoptosis during Infection*

Rotavirus Nonstructural Protein 4 (NSP4)-Viral Enterotoxin with Multiple roles in Pathogenesis of Diarrhoea in Children

Article history: Received on: 06/05/2015 Revised on: 24/05/2015 Accepted on: 14/07/2015 Available online: 27/07/2015 Nonstructural protein 4 (NSP4) of Rotavirus has been designated as the first viral enterotoxin. Its role in viral replication is already well known. Intensive research over the past decade has shown the involvement of this protein in many cellular activities both in ‘expressed’ a...

Nonstructural protein of infectious bursal disease virus inhibits apoptosis at the early stage of virus infection.

Infectious bursal disease virus (IBDV), the causative agent of a highly contagious disease in chickens, carries a small nonstructural protein (NS). This protein has been implicated to play a role in the induction of apoptosis. In this study, we investigate the kinetics of viral replication during a single round of viral replication and examine the mechanism of IBDV-induced apoptosis. Our result...

Occurrence of Staphylococcus Aureus-Induced Apoptosis During Infection, Strategy for Cancer Treatment

Introduction: Despite advances in the recognition of new risk factors, prevention, diagnosis and treatment, cancer is still remains as a global health problem. Several numbers of studies have recently provided evidence that because of having pro apoptotic effects, biotoxins such as bacterial toxins, could be used as potential antitumor agents. Staphylococcus aureus, as a major human pathogen, h...

Early Stage of Virus Infection Disease Virus Inhibits Apoptosis at the Nonstructural Protein of Infectious Bursal

Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks

Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...